Western blot analysis of extracts of various cell lines, using BAP1 antibody ( A6533) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
BAP1 Rabbit pAb
Catalog No:AB-A6533
Manufacturer:ABclonal
Synonyms:BAP1;HUCEP-13;UCHL2;hucep-6
Applications:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | BAP1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-729 of human BAP1 (NP_004647.1). |
Gene ID: | 8314 |
Swiss prot: | Q92560 |
Molecular weight: | 80kDa |
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