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Western blot analysis of extracts of H460 cells, using ATM Antibody (A5908) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
ATM Rabbit pAb
Catalog No：AB-A5908
Manufacturer：ABclonal
Synonyms：AT1;ATA;ATC;ATD;ATDC;ATE;TEL1;TELO1;ATM
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | ATM Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human ATM (NP_000042.3). |
| Gene ID: | 472 |
| Swiss prot: | Q13315 |
| Molecular weight: | 350kDa |
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