Western blot analysis of extracts of various cell lines, using CYP2A6 Antibody (A5815) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
CYP2A6 Rabbit pAb
Catalog No:AB-A5815
Manufacturer:ABclonal
Synonyms:CYP2A6;CPA6;CYP2A;CYP2A3;CYPIIA6;P450C2A;P450PB
Applications:WB
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | CYP2A6 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 215-494 of human CYP2A6 (NP_000753.3). |
Gene ID: | 1548 |
Swiss prot: | P11509 |
Molecular weight: | 56kDa |
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