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Western blot analysis of extracts of various cell lines, using RANTES antibody (A5630) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
RANTES Rabbit pAb
Catalog No：AB-A5630
Manufacturer：ABclonal
Synonyms：CCL5;D17S136E;RANTES;SCYA5;SIS-delta;SISd;TCP228;eoCP
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | RANTES Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-91 of human RANTES (NP_002976.2). |
| Gene ID: | 6352 |
| Swiss prot: | P13501 |
| Molecular weight: | 9kDa |
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