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Western blot analysis of extracts of A375 cells, using PMEL antibody (A5384) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 3min.
PMEL Rabbit pAb
Catalog No：AB-A5384
Manufacturer：ABclonal
Synonyms：PMEL;D12S53E;ME20;ME20-M;ME20M;P1;P100;PMEL17;SI;SIL;SILV;gp100
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | PMEL Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human PMEL (NP_008859.1). |
| Gene ID: | 6490 |
| Swiss prot: | P40967 |
| Molecular weight: | 60kDa/66kDa/70kDa |
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