Western blot analysis of extracts of various cell lines, using HAAO antibody (A4559) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
HAAO Rabbit pAb
Catalog No:AB-A4559
Manufacturer:ABclonal
Synonyms:HAAO;3-HAO;HAO
Applications:WB
Reactivity:Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | HAAO Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2). |
Gene ID: | 23498 |
Swiss prot: | P46952 |
Molecular weight: | 17kDa/32kDa |
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