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Western blot analysis of extracts of various cell lines, using DNA DNA topoisomerase II alpha (TOP2A) (TOP2A) Rabbit mAb (A4389) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 3s.
DNA topoisomerase II alpha (TOP2A) Rabbit mAb
Catalog No：AB-A4389
Manufacturer：ABclonal
Synonyms：TOP2, TP2A
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | DNA topoisomerase II alpha (TOP2A) Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010] |
| Immunogen: | A synthesized peptide derived from human DNA DNA topoisomerase II alpha (TOP2A) (TOP2A) |
| Gene ID: | 7153 |
| Swiss prot: | P11388 |
| Molecular weight: | 174kDa |
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