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Western blot analysis of extracts of various cell lines, using CD59 Rabbit mAb (A4090) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
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Immunohistochemistry of paraffin-embedded rat testis using CD59 Rabbit mAb (A4090) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse testis using CD59 Rabbit mAb (A4090) at dilution of 1:100 (40x lens).
CD59 Rabbit mAb
Catalog No：AB-A4090
Manufacturer：ABclonal
Synonyms：16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | CD59 Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Immunogen: | A synthesized peptide derived from human CD59 |
| Gene ID: | 966 |
| Swiss prot: | P13987 |
| Molecular weight: | 16kDa |
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