Western blot analysis of extracts of various cell lines, using PFKFB3 Rabbit mAb (A3934) at 1:500 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
PFKFB3 Rabbit mAb
Catalog No:AB-A3934
Manufacturer:ABclonal
Synonyms:IPFK2, PFK2, iPFK-2
Applications:WB,IHC
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €485,00
Product Name: | PFKFB3 Rabbit mAb |
Category: | Monoclonal Antibodies |
Description: | The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] |
Immunogen: | A synthesized peptide derived from human PFKFB3 |
Gene ID: | 5209 |
Swiss prot: | Q16875 |
Molecular weight: | 60kDa |
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