Western blot analysis of extracts of various cell lines, using DDB1 antibody (A3827) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
DDB1 Rabbit pAb
Catalog No:AB-A3827
Manufacturer:ABclonal
Synonyms:DDB1;DDBA;UV-DDB1;XAP1;XPCE;XPE;XPE-BF
Applications:WB,IHC
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | DDB1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) – an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1000 to the C-terminus of human DDB1 (NP_001914.3). |
Gene ID: | 1642 |
Swiss prot: | Q16531 |
Molecular weight: | 50kDa/126kDa |
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