TPMT Rabbit pAb
Catalog No:AB-A1017
Manufacturer:ABclonal
Synonyms:TPMT;TPMTD
Applications:WB,IF
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | TPMT Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPMT (NP_000358.1). |
Gene ID: | 7172 |
Swiss prot: | P51580 |
Molecular weight: | 28kDa |
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