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Western blot analysis of extracts of various cell lines, using SHIP11 Rabbit mAb (A3571) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
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Immunohistochemistry of paraffin-embedded human spleen using SHIP11 Rabbit mAb (A3571) at dilution of 1:100 (40x lens).
SHIP1 Rabbit mAb
Catalog No：AB-A3571
Manufacturer：ABclonal
Synonyms：SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | SHIP1 Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| Immunogen: | A synthesized peptide derived from human SHIP11 |
| Gene ID: | 3635 |
| Swiss prot: | Q92835 |
| Molecular weight: | 140kDa |
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