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Western blot analysis of extracts of various cell lines, using CXCR2 antibody (A3301) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
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Immunohistochemistry of paraffin-embedded Mouse spleen using CXCR2 Rabbit pAb (A3301) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded Rat spleen using CXCR2 Rabbit pAb (A3301) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded Human spleen using CXCR2 Rabbit pAb (A3301) at dilution of 1:100 (40x lens).
CXCR2 Rabbit pAb
Catalog No：AB-A3301
Manufacturer：ABclonal
Synonyms：CXCR2;CD182;CDw128b;CMKAR2;IL8R2;IL8RA;IL8RB
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | CXCR2 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. |
| Immunogen: | Recombinant protein of human CXCR2. |
| Gene ID: | 3579 |
| Swiss prot: | P25025 |
| Molecular weight: | 40kDa |
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