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Western blot analysis of extracts of various cell lines, using GRPR antibody (A2940) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 15s.
GRPR Rabbit pAb
Catalog No：AB-A2940
Manufacturer：ABclonal
Synonyms：GRPR;BB2;BB2R
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | GRPR Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1). |
| Gene ID: | 2925 |
| Swiss prot: | P30550 |
| Molecular weight: | 43kDa |
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