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Western blot analysis of extracts of Jurkat cells, using PTPRC antibody (A2115) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 180.
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Immunohistochemistry of paraffin-embedded human colon using CD45 Rabbit pAb (A2115) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human lung using CD45 Rabbit pAb (A2115) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human prostate cancer using CD45 Rabbit pAb (A2115) at dilution of 1:100 (40x lens).
CD45 Rabbit pAb
Catalog No：AB-A2115
Manufacturer：ABclonal
Synonyms：B220;CD45;CD45R;GP180;L-CA;LCA;LY5;T200;PTPRC
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | CD45 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 890-990 of human CD45 (NP_002829.2). |
| Gene ID: | 5788 |
| Swiss prot: | P08575 |
| Molecular weight: | 130kDa/147kDa |
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