Western blot analysis of extracts of various cell lines, using RBL1 antibody (A20518) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 120s.
RBL1 Rabbit pAb
Catalog No:AB-A20518
Manufacturer:ABclonal
Synonyms:PRB1; p107; CP107
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€125,00 – €370,00
Product Name: | RBL1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBL1 (NP_002886.2). |
Gene ID: | 5933 |
Swiss prot: | P28749 |
Molecular weight: | 120kDa |
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