Western blot analysis of extracts of Mouse brain, using SHANK3 antibody (A20488) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 180s.
SHANK3 Rabbit pAb
Catalog No:AB-A20488
Manufacturer:ABclonal
Synonyms:PSAP2; SCZD15; PROSAP2; SPANK-2; DEL22q13.3
Applications:WB,IHC
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€125,00 – €370,00
Product Name: | SHANK3 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. |
Immunogen: | Recombinant protein of human SHANK3. |
Gene ID: | 85358 |
Swiss prot: | Q9BYB0 |
Molecular weight: | 184kDa |
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