1ug/ml of biotinylated PD-L1/CD274 protein was incubated with PD-L1/CD274 Rabbit mAb (A20270) or control mAb with serial dilution for 1 hour at RT. The mixture was added to ELISA plate coated with 1ug/ml of recombinant expressed PD-1. HRP-Streptavidin was used for biotinylated PD-L1/CD274 detection.
PD-L1/CD274 Rabbit mAb
Catalog No:AB-A20270
Manufacturer:ABclonal
Synonyms:B7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274
Applications:ELISA,WB,FC,Inhibition
Reactivity:Human
Host:Rabbit
Conjugate:No
€245,00 – €370,00
Product Name: | PD-L1/CD274 Rabbit mAb |
Category: | Monoclonal Antibodies |
Description: | Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies. |
Immunogen: | Recombinant protein of human PD-L1/CD274. |
Gene ID: | 29126 |
Swiss prot: | Q9NZQ7 |
Molecular weight: | 20kDa/33kDa |
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