Western blot analysis of extracts of various cell lines, using sestrin 1 Rabbit mAb (A19787) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 180s.
sestrin 1 Rabbit mAb
Catalog No:AB-A19787
Manufacturer:ABclonal
Synonyms:PA26, SEST1
Applications:WB,IHC
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €485,00
Product Name: | sestrin 1 Rabbit mAb |
Category: | Monoclonal Antibodies |
Description: | This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
Immunogen: | A synthesized peptide derived from human sestrin 1 |
Gene ID: | 27244 |
Swiss prot: | Q9Y6P5 |
Molecular weight: | 70kDa |
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