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Immunohistochemistry of paraffin-embedded mouse brain using PRKAR2B Rabbit mAb (A19745) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded rat ovary using PRKAR2B Rabbit mAb (A19745) at dilution of 1:100 (40x lens).
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Western blot analysis of extracts of various cell lines, using PRKAR2B Rabbit mAb (A19745) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 180s.
PRKAR2B Rabbit mAb
Catalog No：AB-A19745
Manufacturer：ABclonal
Synonyms：PRKAR2, RII-BETA
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | PRKAR2B Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008] |
| Immunogen: | A synthesized peptide derived from human PRKAR2B |
| Gene ID: | 5577 |
| Swiss prot: | P31323 |
| Molecular weight: | 46kDa |
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