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Western blot analysis of extracts of various cell lines, using Raf1 antibody (A19638) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 3min.
Raf1 Rabbit mAb
Catalog No：AB-A19638
Manufacturer：ABclonal
Synonyms：CMD1NN;CRAF;NS5;Raf-1;c-Raf;RAF1
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | Raf1 Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] |
| Immunogen: | A synthesized peptide derived from human Raf1 . |
| Gene ID: | 5894 |
| Swiss prot: | P04049 |
| Molecular weight: | 74kDa |
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