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Western blot analysis of extracts of various cell lines, using WASPP Antibody (A0978) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).
WASP Rabbit pAb
Catalog No：AB-A0978
Manufacturer：ABclonal
Synonyms：WAS;IMD2;SCNX;THC;THC1;WASP;WASPA
Applications：WB,IF
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | WASP Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5′ UTR sequence, has been described, however, its full-length nature is not known. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human WASPP (NP_000368.1). |
| Gene ID: | 7454 |
| Swiss prot: | P42768 |
| Molecular weight: | 52kDa |
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