Western blot analysis of extracts of various cell lines, using Cathepsin B antibody (A0967) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
Cathepsin B Rabbit pAb
Catalog No:AB-A0967
Manufacturer:ABclonal
Synonyms:APPS;CPSB;Cathepsin B;CTSB
Applications:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | Cathepsin B Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer’s disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human Cathepsin B (NP_001899.1). |
Gene ID: | 1508 |
Swiss prot: | P07858 |
Molecular weight: | 37kDa |
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