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Immunohistochemistry of paraffin-embedded human esophageal cancer using CDKN1A/p21CIP1 Rabbit mAb (A19094) at dilution of 1:100 (40x lens).
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Western blot analysis of extracts of various cell lines, using CDKN1A/p21CIP1 antibody (A19094) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 3min.
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Western blot analysis of extracts from normal (control) and CDKN1A/p21CIP1 knockout (KO) 293T cells, using CDKN1A/p21CIP1 antibody (A19094) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 3min.
[KO Validated] CDKN1A/p21CIP1 Rabbit mAb
Catalog No：AB-A19094
Manufacturer：ABclonal
Synonyms：CAP20;CDKN1;CIP1;MDA-6;P21;SDI1;WAF1;p21CIP1;CDKN1A
Applications：WB,IHC
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | [KO Validated] CDKN1A/p21CIP1 Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015] |
| Immunogen: | A synthesized peptide derived from human CDKN1A/p21CIP1 |
| Gene ID: | 1026 |
| Swiss prot: | P38936 |
| Molecular weight: | 21kDa |
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