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Western blot analysis of extracts of various cell lines, using HMGCR antibody (A19063) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
HMGCR Rabbit mAb
Catalog No：AB-A19063
Manufacturer：ABclonal
Synonyms：HMGCR;LDLCQ3;HMGCR
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | HMGCR Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| Immunogen: | A synthesized peptide derived from human HMGCR |
| Gene ID: | 3156 |
| Swiss prot: | P04035 |
| Molecular weight: | 97kDa |
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