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Western blot analysis of extracts of various cell lines, using CASP1 antibody (A18646) at 1:500 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 3min.
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Western blot analysis of extracts from normal (control) and CASP1 knockout (KO) HeLa cells, using CASP1 antibody (18646) at 1:500 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 3min.
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Immunohistochemistry of paraffin-embedded Rat ovary using CASP1 antibody (A18646) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded Human liver cancer using CASP1 antibody (A18646) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded Mouse kidney using CASP1 antibody (A18646) at dilution of 1:100 (40x lens).
[KO Validated] CASP1 Rabbit pAb
Catalog No：AB-A18646
Manufacturer：ABclonal
Synonyms：CASP1; ICE; IL1BC; P45; caspase-1
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €245,00
| Product Name: | [KO Validated] CASP1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. |
| Immunogen: | Recombinant protein of human CASP1. |
| Gene ID: | 834 |
| Swiss prot: | P29466 |
| Molecular weight: | 10kDa/29kDa/35kDa/42kDa/45kDa |
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