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Western blot analysis of extracts of various cell lines, using CSK antibody (A0735) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
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Western blot analysis of extracts of various cell lines, using CSK antibody (A0735) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
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Western blot analysis of extracts from normal (control) and CSK knockout (KO) 293T cells, using CSK antibody (A0735) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
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Immunohistochemistry of paraffin-embedded rat spleen using [KO Validated] CSK Rabbit pAb (A0735) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human colon carcinoma using [KO Validated] CSK Rabbit pAb (A0735) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse spleen using [KO Validated] CSK Rabbit pAb (A0735) at dilution of 1:100 (40x lens).
[KO Validated] CSK Rabbit pAb
Catalog No：AB-A0735
Manufacturer：ABclonal
Synonyms：CSK
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | [KO Validated] CSK Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 241-450 of human CSK (NP_004374.1). |
| Gene ID: | 1445 |
| Swiss prot: | P41240 |
| Molecular weight: | 50kDa |
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