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Western blot analysis of extracts of various cell lines, using CBL antibody (A0732) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
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Immunohistochemistry of paraffin-embedded human prostate using CBL antibody (A0732) at dilution of 1:200 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse lung using CBL antibody (A0732) at dilution of 1:200 (40x lens).
CBL Rabbit pAb
Catalog No：AB-A0732
Manufacturer：ABclonal
Synonyms：C-CBL;CBL2;FRA11B;NSLL;RNF55;CBL;c-Cbl
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | CBL Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5′ UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 637-906 of human CBL (NP_005179.2). |
| Gene ID: | 867 |
| Swiss prot: | P22681 |
| Molecular weight: | 99kDa |
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