Western blot analysis of extracts from normal (control) and Cortactin knockout (KO) HeLa cells, using Cortactin antibody (A18038) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
[KO Validated] Cortactin Rabbit pAb
Catalog No:AB-A18038
Manufacturer:ABclonal
Synonyms:CTTN;EMS1;cortactin
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €485,00
Product Name: | [KO Validated] Cortactin Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Cortactin (NP_612632.1). |
Gene ID: | 2017 |
Swiss prot: | Q14247 |
Molecular weight: | 57kDa/61kDa/70kDa |
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