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Western blot analysis of extracts of various cell lines, using Calreticulineticulin antibody (A18013) at 1:500 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 30s.
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Immunohistochemistry of paraffin-embedded human brain using [KO Validated] Calreticulineticulin Rabbit pAb (A18013) at dilution of 1:100 (40x lens).
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Western blot analysis of extracts from normal (control) and Calreticulineticulin knockout (KO) HeLa cells, using Calreticulineticulin antibody (A18013) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
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Immunohistochemistry of paraffin-embedded rat brain using [KO Validated] Calreticulineticulin Rabbit pAb (A18013) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded rat kidney using [KO Validated] Calreticulineticulin Rabbit pAb (A18013) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human thyroid cancer using [KO Validated] Calreticulineticulin Rabbit pAb (A18013) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human colon carcinoma using [KO Validated] Calreticulineticulin Rabbit pAb (A18013) at dilution of 1:100 (40x lens).
[KO Validated] Calreticulin Rabbit pAb
Catalog No：AB-A18013
Manufacturer：ABclonal
Synonyms：CALR;CRT;HEL-S-99n;RO;SSA;cC1qR
Applications：WB,IHC,IF,IP
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | [KO Validated] Calreticulin Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-417 of human Calreticulineticulin (NP_004334.1). |
| Gene ID: | 811 |
| Swiss prot: | P27797 |
| Molecular weight: | 48kDa |
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