Western blot analysis of extracts of various cell lines, using SENP6 antibody (A17673) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 30s.
SENP6 Rabbit pAb
Catalog No:AB-A17673
Manufacturer:ABclonal
Synonyms:SSP1;SUSP1;SENP6
Applications:WB
Reactivity:Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | SENP6 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009] |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 811-1112 of human SENP6 (NP_056386.2). |
Gene ID: | 26054 |
Swiss prot: | Q9GZR1 |
Molecular weight: |
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