Western blot analysis of extracts of various cell lines, using JAB1/CSN5/JAB1/CSN5/COPS5 Rabbit pAb (A1766) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
JAB1/CSN5/COPS5 Rabbit pAb
Catalog No:AB-A1766
Manufacturer:ABclonal
Synonyms:COPS5;CSN5;JAB1;MOV-34;SGN5
Applications:WB,IHC
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | JAB1/CSN5/COPS5 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human JAB1/CSN5/JAB1/CSN5/COPS5 (NP_006828.2). |
Gene ID: | 10987 |
Swiss prot: | Q92905 |
Molecular weight: | 37kDa |
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