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Western blot analysis of extracts of various cell lines, using UBE3A antibody (A1757) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
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Immunohistochemistry of paraffin-embedded rat brain using UBE3A Rabbit pAb (A1757) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human liver cancer using UBE3A Rabbit pAb (A1757) at dilution of 1:100 (40x lens).
UBE3A Rabbit pAb
Catalog No：AB-A1757
Manufacturer：ABclonal
Synonyms：UBE3A;ANCR;AS;E6-AP;EPVE6AP;HPVE6A
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | UBE3A Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-590 of human UBE3A (NP_570853.1). |
| Gene ID: | 7337 |
| Swiss prot: | Q05086 |
| Molecular weight: | 97kDa/100kDa |
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