HLA-DPA1 Rabbit pAb
Catalog No:AB-A1754
Manufacturer:ABclonal
Synonyms:HLA-DPA1;DP(W3);DP(W4);HLA-DP1A;HLADP;HLASB;PLT1;class II
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | HLA-DPA1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-220 of human HLA-DPA1 (NP_291032.2). |
Gene ID: | 3113 |
Swiss prot: | P20036 |
Molecular weight: | 29kDa |
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