CLCN3 Rabbit pAb
Catalog No:AB-A17452
Manufacturer:ABclonal
Synonyms:CLCN3;CLC3;ClC-3
Applications:WB
Reactivity:Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €325,00
Product Name: | CLCN3 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
Immunogen: | A synthetic peptide of human CLCN3. |
Gene ID: | 1182 |
Swiss prot: | P51790 |
Molecular weight: | 88kDa/90kDa/96kDa |
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