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Western blot analysis of extracts of various cell lines, using MLKL antibody (A17312) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
MLKL Rabbit pAb
Catalog No：AB-A17312
Manufacturer：ABclonal
Synonyms：hMLKL;MLKL
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | MLKL Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. |
| Immunogen: | Recombinant protein of human MLKL |
| Gene ID: | 197259 |
| Swiss prot: | Q8NB16 |
| Molecular weight: | 53kDa/54kDa |
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