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Western blot analysis of extracts of THP-1 cells, using Caspase-1 antibody (A16792) at 1:500 dilution.THP-1 cells were treated by PMA/TPA (80 nM) at 37℃ for overnight and LPS (1 μg/ml) at 37℃ for 6 hours.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
Caspase-1 Rabbit pAb
Catalog No：AB-A16792
Manufacturer：ABclonal
Synonyms：CASP1;ICE;IL1BC;P45;caspase-1;Caspase 1
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | Caspase-1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. |
| Immunogen: | Recombinant protein of human Caspase-1. |
| Gene ID: | 834 |
| Swiss prot: | P29466 |
| Molecular weight: | 10kDa/29kDa/35kDa/42kDa/45kDa |
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