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Western blot analysis of extracts of Mouse heart, using STX17 antibody (A16715) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
TPO-R/CD110/c-Mpl Rabbit pAb
Catalog No：AB-A16715
Manufacturer：ABclonal
Synonyms：MPL;C-MPL;CD110;MPLV;THCYT2;TPOR
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | TPO-R/CD110/c-Mpl Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. |
| Immunogen: | Recombinant Protein of human TPO-R/CD110/c-TPO-R/CD110/c-Mpl |
| Gene ID: | 4352 |
| Swiss prot: | P40238 |
| Molecular weight: | 71kDa |
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Conjugate：No
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Conjugate：No
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Conjugate：No
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Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
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Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
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