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Western blot analysis of extracts of Rat brain, using HMGCR Rabbit pAb (A1633) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
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Western blot analysis of extracts of Mouse spleen, using HMGCR Rabbit pAb (A1633) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
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Immunohistochemistry of paraffin-embedded human uterine cancer using HMGCR antibody (A1633) at dilution of 1:200 (40x lens).
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Immunohistochemistry of paraffin-embedded human small intestine using HMGCR antibody (A1633) at dilution of 1:200 (40x lens).
HMGCR Rabbit pAb
Catalog No：AB-A1633
Manufacturer：ABclonal
Synonyms：HMGCR;LDLCQ3;HMGCR
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | HMGCR Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 629-888 of human HMGCR (NP_000850.1). |
| Gene ID: | 3156 |
| Swiss prot: | P04035 |
| Molecular weight: | 92kDa/97kDa/99kDa |
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