EMP2 Rabbit pAb
Catalog No:AB-A16327
Manufacturer:ABclonal
Synonyms:EMP2;XMP
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €325,00
Product Name: | EMP2 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human EMP2 (NP_001415.1). |
Gene ID: | 2013 |
Swiss prot: | P54851 |
Molecular weight: | 19kDa |
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