Western blot analysis of extracts of various cell lines, using FAR1 antibody (A16284) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
FAR1 Rabbit pAb
Catalog No:AB-A16284
Manufacturer:ABclonal
Synonyms:FAR1;MLSTD2;PFCRD;SDR10E1
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | FAR1 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human FAR1 (NP_115604.1). |
Gene ID: | 84188 |
Swiss prot: | Q8WVX9 |
Molecular weight: | 59kDa |
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