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Western blot analysis of extracts of rat liver, using PXR antibody (A1583) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
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Immunohistochemistry of paraffin-embedded rat testis using PXR antibody (A1583) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded rat pancreas using PXR antibody (A1583) at dilution of 1:100 (40x lens).
PXR Rabbit pAb
Catalog No：AB-A1583
Manufacturer：ABclonal
Synonyms：NR1I2;BXR;ONR1;PAR;PAR1;PAR2;PARq;PRR;PXR;SAR;SXR
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | PXR Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PXR (NP_071285.1). |
| Gene ID: | 8856 |
| Swiss prot: | O75469 |
| Molecular weight: | 39kDa/43kDa/45kDa/48kDa/49kDa/52kDa/53kDa |
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