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Western blot analysis of extracts of various cell lines, using Bcl-XL antibody (A0209) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 15s.
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Immunohistochemistry of paraffin-embedded rat kidney using Bcl-XL Rabbit pAb (A0209) at dilution of 1:100 (40x lens).
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Immunofluorescence analysis of C6 cells using Bcl-XL Rabbit pAb (A0209) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat kidney using Bcl-XL Rabbit pAb (A0209) at dilution of 1:100 (40x lens).
Bcl-XL Rabbit pAb
Catalog No：AB-A0209
Manufacturer：ABclonal
Synonyms：BCL2L1;BCL-XL/S;BCL2L;BCLX;Bcl-X;PPP1R52;BCL2 like 1;Bcl-XL
Applications：WB,IHC,IF,IP
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | Bcl-XL Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Bcl-XL (NP_612815.1). |
| Gene ID: | 598 |
| Swiss prot: | Q07817 |
| Molecular weight: | 18kDa/25-26kDa |
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