The c-MET gene encodes a tyrosine kinase-type receptor, and its ligand is hepatocyte growth factor (HGF). c-MET is the only known HGF high-affinity receptor. HGF activates c-MET after binding to c-MET, which causes cell proliferation, migration, differentiation and morphological changes and plays an important physiological function. Abnormal activation of HGF/c-MET signaling pathway can promote the occurrence, development and metastasis of various malignant tumors. It has been demonstrated that c-MET gene is mutated, amplified and overexpressed in a variety of cancers such as lung cancer, breast cancer, head and neck squamous cell carcinoma, liver cancer, esophageal cancer, gastric cancer, and colorectal cancer.

This product uses immunohistochemical (IHC) method to qualitatively detect the level of c-MET protein expression in cancer tissues.