Western blot analysis of extracts of rat heart, using CAPN6 antibody (A13777) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
CAPN6 Rabbit pAb
Catalog No:AB-A13777
Manufacturer:ABclonal
Synonyms:CAPN6;CANPX;CAPNX;CalpM;DJ914P14.1;calpain-6
Applications:WB
Reactivity:Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | CAPN6 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CAPN6 (NP_055104.2). |
Gene ID: | 827 |
Swiss prot: | Q9Y6Q1 |
Molecular weight: | 74kDa |
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