Pannexin-1 (Panx1), Mimetic Blocking Peptide
Catalog No:CP-SIGN-011
Manufacturer:CPC Scientific
Size:1 mg
MWt:1,242
€183,00
Product Name: | Pannexin-1 (Panx1), Mimetic Blocking Peptide |
Category: | Peptides |
Three letter sequence: | Trp-Arg-Gln- Ala-Ala-Phe- Val-Asp-Ser- Tyr |
One letter sequence: | WRQAAFVDSY |
Description: | This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP- gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of |
Literature References: | Pelegrin, P. et al. EMBO. J. 25, 5071 (2006); Pelegrin, P. et al.t J. Biol. Chem. 282, 2386 (2007). |
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