[Lys(Me2)372]- p53 (368-393), p53 K372(Me2), biotin-labeled, human
Catalog No:CP-CANC-012B
Manufacturer:CPC Scientific
Size:1 mg
MWt:3,467
€411,00
Product Name: | [Lys(Me2)372]- p53 (368-393), p53 K372(Me2), biotin-labeled, human |
Category: | Peptides |
Three letter sequence: | Biotin-Lys- Gly-Gly-His- Leu-Lys-Ser- Lys(Me2)- Lys-Gly-Gln- Ser-Thr-Ser- Arg-His-Lys- Lys-Leu-Met- Phe-Lys-Thr- Glu-Gly-Pro- Asp-Ser-Asp- NH2 |
One letter sequence: | Biotin- KGGHLKS- K(Me2)- KGQSTSRHKKL MFKTEGPDSD- NH2 |
Description: | This is a biotin- labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with dimethylation at Lys372 and additional KGW residues on its N- terminus. Methylation at Lys372 activates p53 and induces upregulation of target gene p21. Methylation at Lys372 also inhibits Lys370 methylation by interfering with Smyd2, a lysine methyltransferase, and p53 interaction. Lys 370 methylation reduces p53 transcriptional |
Literature References: | Huang, J. et al. Nature 440, 629 (2006). |
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