(Ala1)-PAR-4 (1-6) amide (mouse)
Catalog No:CP-PARP-015B
Manufacturer:CPC Scientific
Size:5 mg
CAS No.:352017-71-1
Formula:C34H48N 8O7
MWt:681
€217,00
Product Name: | (Ala1)-PAR-4 (1-6) amide (mouse) |
Category: | Peptides |
Three letter sequence: | H-Ala-Tyr- Pro-Gly-Lys- Phe-NH2 Trifluoroacet ate salt |
One letter sequence: | AYPGKF-NH2 |
Description: | This peptide based on the proteolytically- revealed tethered ligand sequence of the murine proteinase-activated receptor-4 (PAR-4) was shown to cause platelet aggregation with an EC50 value of about 15 碌M. PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation. |
Literature References: | T.R.Faruqi et al., J. Biol. Chem., 275, 19728 (2000) M.D.Hollenberg and M.Saifeddine, Can. J. Physiol. Pharmacol., 79, 439 (2001) R.A.Henriksen and V.K.Hanks, Arterioscler. Thromb. Vasc. Biol., 22, 861 (2002) Ref: Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003); Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005). |
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