Neuropeptide W-23 (human)
Catalog No:CP-NEUP-013A
Manufacturer:CPC Scientific
Size:1 mg
CAS No.:383415-79-0
Formula:C119H183 N35O28S
MWt:2,584
€279,00
Product Name: | Neuropeptide W-23 (human) |
Category: | Peptides |
Three letter sequence: | Trp-Tyr-Lys- His-Val-Ala- Ser-Pro-Arg- Tyr-His-Thr- Val-Gly-Arg- Ala-Ala-Gly- Leu-Leu-Met- Gly-Leu Trifluoroacet ate salt |
One letter sequence: | WYKHVASPRY HTVGRAAGLL MGL |
Description: | This peptide is an endogenous ligand of the G-protein- coupled receptors GPR7 and GPR8. It dose-dependently inhibited cAMP accumulation induced by forskolin in CHO-GPR7 and CHO-GPR8 cells, with IC50 values of 0.025 and 0.178 nM, respectively. Intracerebroventricul ar administration of neuropeptide W-23 (human) in rats increased food intake and stimulated prolactin release. |
Literature References: | .Shimomura et al., J. Biol. Chem., 277, 35826 (2002) S.Brezillon et al., J. Biol. Chem., 278, 776 (2003) H.Tanaka et al., Proc. Natl. Acad. Sci. USA, 100, 6251 (2003) M.S.Mondal et al., Endocrinology, 144, 4729 (2003) |
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