Histrelin
Catalog No:CP-LHRH-014B
Manufacturer:CPC Scientific
Size:10 mg
CAS No.:220810-26-4
Formula:C66H86N 18O12
MWt:1,324
€672,00
Product Name: | Histrelin |
Category: | Peptides |
Three letter sequence: | Pyr-His-Trp- Ser-Tyr-D- His(Bzl)-Leu- Arg-Pro- NHEt Acetate salt |
One letter sequence: | Pyr- HWSYh(Bzl)- LRP-NHEt |
Description: | As a potent LHRH agonist, histrelin stimulates LH and FSH release and inhibits the actions of sex steroids on the male and female reproductive tracts. Its potency in vivo and in vitro is similar to that of the D-Trp6- containing analog. Especially because of its high water solubility and greater lipophilic character, histrelin appears promising for clinical application.Slow- release implants containing histreline implants were approved for the palliative treatment of advanced hormone-dependent prostate cancer. |
Literature References: | K.Sundaram et al., Life Sci., 28, 83 (1981) J.DeFazio et al., Endocr. Res., 10, 163 (1984) M.J.Gibson and D.S.Kohtz, Contraception, 31, 91 (1985) M.J.Karten and J.E.Rivier, Endocr. Rev., 7, 44 (1986) G.C.Doelle et al., Horm. Metab. Res., 18, 201 (1986) J.W.Gunnet et al., J. Endocrinol., 131, 211 (1991) M.Montagner et al., Reprod. Fertil. Dev., 17, 222 (2005) Merck Index, 14th ed., No. 4722, (2006) |
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